Comment 13 for bug 913444

For as long as I can remember, I always have to run winecfg, navigate to Desktop Integration, and untick "Link to" for every path whenever I load a new Wineprefix after changing Wine builds. I vaguely recall that even just applying a patch seems to cause your customisations getting overridden.

This is currently the most annoying bug in Wine that's not compatibility-related.