Comment 36 for bug 371897

@Robert Shaw: I've experienced the exact same problem with audio dropping out entirely while in WoW using Niel's Wine-pulse. For the record, apparently you don't need to restart it entirely; you can just get WoW to reinitialize its audio stack by going into sound preferences and toggling "use hardware" (which doesn't seem to do anything in wine, as far as I can tell, but does get it to give audio a kick-start).