This problem has re-appeared. It's not exactly the same, it did it after a cold boot and I had a fight getting it working. Interfaces have unique mac addresses, but one or all of them remained unresponsive after a boot or a down/up. Uname now: 2.6.32.16-141.fc12.i686 Picked this up in dmesg: Aug 4 19:35:18 turnstile kernel: ------------[ cut here ]------------ Aug 4 19:35:18 turnstile kernel: WARNING: at net/sched/sch_generic.c:261 dev_watchdog+0xc6/0x158() Aug 4 19:35:18 turnstile kernel: Hardware name: Aug 4 19:35:18 turnstile kernel: NETDEV WATCHDOG: eth0 (r8169): transmit queue 0 timed out Aug 4 19:35:18 turnstile kernel: Modules linked in: xt_multiport ipt_LOG act_nat ebt_dnat ebt_snat ebtable_nat ebtables iptable_nat nf_nat_snmp_basic nf_nat_proto_udplite nf_nat_sip nf_nat_irc nf_nat_ftp nf_nat_pptp nf_nat_proto_gre nf_nat_proto_dccp nf_nat_amanda nf_nat_proto_sctp libcrc32c nf_nat_tftp nf_nat_h323 nf_nat nf_conntrack_irc nf_conntrack_ftp nf_conntrack_netbios_ns ts_kmp nf_conntrack_amanda nf_conntrack_proto_udplite nf_conntrack_proto_sctp nf_conntrack_sip nf_conntrack_netlink nfnetlink nf_conntrack_tftp nf_conntrack_pptp nf_conntrack_proto_gre nf_conntrack_sane nf_conntrack_proto_dccp nf_conntrack_h323 nf_conntrack_ipv6 ip6t_LOG ip6table_filter ip6_tables cpufreq_ondemand acpi_cpufreq sit tunnel4 ipv6 dm_multipath uinput i2c_viapro i2c_core via_rhine r8169 mii pata_acpi ata_generic firewire_ohci sata_via firewire_core crc_itu_t [last unloaded: scsi_wait_scan] Aug 4 19:35:18 turnstile kernel: Pid: 0, comm: swapper Not tainted 2.6.32.16-141.fc12.i686 #1 Aug 4 19:35:18 turnstile kernel: Call Trace: Aug 4 19:35:18 turnstile kernel: [] warn_slowpath_common+0x6a/0x81 Aug 4 19:35:18 turnstile kernel: [] ? dev_watchdog+0xc6/0x158 Aug 4 19:35:18 turnstile kernel: [] warn_slowpath_fmt+0x29/0x2c Aug 4 19:35:18 turnstile kernel: [] dev_watchdog+0xc6/0x158 Aug 4 19:35:18 turnstile kernel: [] ? __mod_timer+0x115/0x120 Aug 4 19:35:18 turnstile kernel: [] ? local_bh_enable_ip+0xd/0xf Aug 4 19:35:18 turnstile kernel: [] ? _spin_unlock_bh+0x13/0x15 Aug 4 19:35:18 turnstile kernel: [] ? fib6_run_gc+0xb7/0xbe [ipv6] Aug 4 19:35:18 turnstile kernel: [] run_timer_softirq+0x16d/0x1f0 Aug 4 19:35:18 turnstile kernel: [] ? dev_watchdog+0x0/0x158 Aug 4 19:35:18 turnstile kernel: [] __do_softirq+0xb1/0x157 Aug 4 19:35:18 turnstile kernel: [] do_softirq+0x36/0x41 Aug 4 19:35:18 turnstile kernel: [] irq_exit+0x2e/0x61 Aug 4 19:35:18 turnstile kernel: [] do_IRQ+0x86/0x9a Aug 4 19:35:18 turnstile kernel: [] common_interrupt+0x30/0x38 Aug 4 19:35:18 turnstile kernel: [] ? acpi_idle_enter_simple+0x10f/0x142 Aug 4 19:35:18 turnstile kernel: [] acpi_idle_enter_bm+0xc7/0x287 Aug 4 19:35:18 turnstile kernel: [] cpuidle_idle_call+0x73/0xcb Aug 4 19:35:18 turnstile kernel: [] cpu_idle+0x96/0xb2 Aug 4 19:35:18 turnstile kernel: [] rest_init+0x58/0x5a Aug 4 19:35:18 turnstile kernel: [] start_kernel+0x33c/0x341 Aug 4 19:35:18 turnstile kernel: [] i386_start_kernel+0x9e/0xa5 Aug 4 19:35:18 turnstile kernel: ---[ end trace 58bb370737c8d652 ]--- What's going on ?