Finally I'm able to test on a Threadripper myself now. Note: In regard to the commit that Babu identified - I'm on kernel 5.10.0-1020-oem so that patch would be applied already. I need to find an older kernel to retry with that as well (on that new kernel) I did a full Win10 install and it worked fine for me. In regard to CPU types (for comparison) I got qemu 1:4.2-3ubuntu6.15 / libvirt 6.0.0-0ubuntu8.8: EPYC-Rome AMD With a more recent qemu/libvirt it isn't much different for this chip (there recently were some Milan changes, but those seem not to matter for this chip). qemu 1:5.2+dfsg-9ubuntu1 / libvirt 7.0.0-2ubuntu1 EPYC-Rome AMD I wasn't able to crash this setup with an old (18.04) nor a new 21.04) Ubuntu guest. Installing Win10 worked fine for a while and didn't break as reported. But the setup I have goes through triple ssh-tunnels and around the globe - that slows things down a lot :-/ This is how far I've got: 1. start up the install 2. select no license key -> custom install -> it started copying files 3. it goes into the first reboot After this the latency kills me and virt-manager starts to abort the installation. So far I did not hit (https://launchpadlibrarian.net/529734412/security.png) as reported by David. @David - did this already pass the critical step for you, how early or late in the install did you hit the issues. As I said I'll probably need to find an older kernel anyway (to be before the commit that Babu referenced)