Kernel turns off USB-devices

Kernel turns off USB-devices.
A mouse connected to an usb-port works until some time. Then this device is turned off and never turned on again. I tried to turn off power saving for such devices, but without success.

This started with kernels 5.4.0-49-generic and later. I do not see this with kernel 5.4.0-48-generic.

This bug renders all usb-ports used unusable. You can unplug the device (a mouse or keyboard) to an unused usb-port. But this will be switched off then soon too. At some point in future you are out of working ports, because all of them are switched off and never on again.

ProblemType: Bug
DistroRelease: Ubuntu 20.04
Package: linux-image-5.4.0-52-generic 5.4.0-52.57
ProcVersionSignature: Ubuntu 5.4.0-52.57-generic 5.4.65
Uname: Linux 5.4.0-52-generic x86_64
ApportVersion: 2.20.11-0ubuntu27.10
Architecture: amd64
AudioDevicesInUse:
 USER PID ACCESS COMMAND
 /dev/snd/controlC0: tps 6019 F.... pulseaudio
CasperMD5CheckResult: skip
Date: Mon Oct 19 00:49:09 2020
HibernationDevice: RESUME=/dev/vg/swap_1
InstallationDate: Installed on 2011-10-19 (3287 days ago)
InstallationMedia: Xubuntu 11.10 "Oneiric Ocelot" - Release amd64 (20111012)
MachineType: Acer TravelMate P643-M
ProcFB: 0 i915drmfb
ProcKernelCmdLine: BOOT_IMAGE=/vmlinuz-5.4.0-52-generic root=/dev/mapper/vg-root ro elevator=deadline splash acpi=force reboot=bios ipv6.disable=1 crashkernel=384M-2G:128M,2G-:256M vt.handoff=7
PulseList: Error: command ['pacmd', 'list'] failed with exit code 1: No PulseAudio daemon running, or not running as session daemon.
RelatedPackageVersions:
 linux-restricted-modules-5.4.0-52-generic N/A
 linux-backports-modules-5.4.0-52-generic N/A
 linux-firmware 1.187.3
SourcePackage: linux
UpgradeStatus: Upgraded to focal on 2019-04-27 (540 days ago)
dmi.bios.date: 10/21/2013
dmi.bios.vendor: Phoenix Technologies Ltd.
dmi.bios.version: V2.15
dmi.board.asset.tag: No Asset Tag
dmi.board.name: TravelMate P643-M
dmi.board.vendor: Acer
dmi.board.version: V2.15
dmi.chassis.asset.tag: No Asset Tag
dmi.chassis.type: 9
dmi.chassis.vendor: Acer
dmi.chassis.version: V2.15
dmi.modalias: dmi:bvnPhoenixTechnologiesLtd.:bvrV2.15:bd10/21/2013:svnAcer:pnTravelMateP643-M:pvrV2.15:rvnAcer:rnTravelMateP643-M:rvrV2.15:cvnAcer:ct9:cvrV2.15:
dmi.product.family: TravelMate P643-M
dmi.product.name: TravelMate P643-M
dmi.product.sku: TravelMate P643-M_0681_2.15
dmi.product.version: V2.15
dmi.sys.vendor: Acer