We have upgraded MQ to 7.0.1.0. The same error is still over here. C:\Users\Administrator>dspmqver Name: WebSphere MQ Version: 7.0.1.0 CMVC level: p000-L090813 BuildType: IKAP - (Production) I failed to install pymqi-1.2.win32-py2.7-mq-7.0-client.exe because it looks for 32-bit Python 2.7 in system registry. (The installed Python is 64-bit version which is in 64-bit system registry) I attached the screen sanpshot of error message for your reference. (Embedded image moved to file: pic09429.jpg) The attach files is my test script. I hope it save your time to repeat my case. (See attached file: testTX.py) My current workaround is to build a x86 application distribution pack by using py2exe in a x86 box (Win XP), then distribute that x86 pack to the x64 box (Windows 2008 server) that is enabled WOW64 layer. It works! However, I still expect a native 64-bit solution for better performance and future compatibility. I would like to express my deep appreciation to your great work for PyMQI that makes Python really powerful in our production environment. Regards, Lu, Yuan-Ching/盧元慶 Computer Integrated Manufacturing Department, Manufacturing Operation, TSMC Solid State Lighting Ltd. Tel: 886-3-5636688 Ext: 781-3057 Mobile: 886-938-317596