I'm running LMDE through a live environment via USB stick on a Lenovo S10-3T
Unfortunately I immediately ran into some issues, by default the touchpad was not configured to be used for mouse clicks- I eventually changed the settings via Mouse Preferences to enable mouse clicks on the touchpad. The S10-3 series however has some quirks that still exist with it's touchpad. On this netbook the touchpad space extends over the left and right-click space, the result I'm dealing with is that LMDE doesn't recognize those buttons. This is not something I encountered on UNR (the currently installed distro). The touchpad is recognized as a "SynPS/2 Synaptics TouchPad."
A similar problem was first mentioned in the LMDE Bug Reports Thread, post #313767. Though that post was made without giving hardware specifics, it can be derived from the fact that this poster's machine ran LMDE via a livecd that it is not the same machine as this post, being as this post covers a netbook.
http://forums.linuxmint.com/viewtopic.php?f=47&t=54647#p313767
As this problem does not occur in the Main edition, but does occur under LMDE, I initially thought this then to be a issue with Debian. It looks like this bug however, also occurs in Ubuntu 10.10- See http://